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Soluble Triggering Receptor Expressed on Myeloid Cells 2 From Cerebrospinal Fluid in Sleep Disorders Related to

Mingshu Mo1, Yuting Tang1, Lijian Wei1

  • 1Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Frontiers in Aging Neuroscience
|October 18, 2021
PubMed

Insights

Soluble TREM2 (sTREM2) in cerebrospinal fluid is elevated in Parkinson's disease (PD) patients and correlates with disease severity and sleep disturbances, suggesting its potential as a PD biomarker.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Neurology

Background:

  • Triggering receptor expressed on myeloid cells 2 (TREM2) is a key microglial receptor in the central nervous system.
  • TREM2's role in Parkinson's disease (PD) pathogenesis, particularly its soluble form (sTREM2), remains incompletely understood.
  • Microglial activation and neuroinflammation are increasingly recognized as critical factors in PD progression.

Purpose of the Study:

  • To investigate the concentration of soluble TREM2 (sTREM2) in the cerebrospinal fluid (CSF) of Parkinson's disease patients.
  • To explore the association between CSF sTREM2 levels and PD clinical symptoms, including sleep disturbances.
  • To evaluate the diagnostic potential of CSF sTREM2 as a biomarker for PD and associated sleep disorders.

Main Methods:

  • A case-control study involving 80 sporadic Parkinson's disease patients and 65 healthy controls.
  • Measurement of sTREM2 concentrations in CSF using established assays.
  • Assessment of sleep quality using the Parkinson's Disease Sleep Scale (PDSS) and correlation analysis with sTREM2 levels.

Main Results:

  • CSF sTREM2 levels were significantly elevated in PD patients compared to healthy controls (p < 0.01).
  • CSF sTREM2 showed a positive correlation with CSF alpha-synuclein levels (r = 0.248, p = 0.027) and a negative correlation with PDSS scores (r = -0.555, p < 0.01).
  • Receiver operating characteristic (ROC) curve analysis indicated significant diagnostic value for sTREM2 in PD (AUC = 0.791) and PD-related sleep disorders (AUC = 0.733).

Conclusions:

  • CSF sTREM2 may serve as a potential biomarker for diagnosing Parkinson's disease.
  • Elevated CSF sTREM2 levels are associated with sleep disorders in PD patients, suggesting its predictive value.
  • Further multicenter prospective studies are warranted to validate the diagnostic and predictive utility of CSF sTREM2 in Parkinson's disease.
Keywords:
Parkinson’s diseaseTREM2 (triggering receptor expressed on myeloid cells)biomarkercerebrospinal fluid (CSF)sleep disorder (SD)

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