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Ocular Motor Abnormalities in Anti-IgLON5 Disease
Stefan Macher1, Ivan Milenkovic1, Tobias Zrzavy1
1Department of Neurology, Medical University of Vienna, Vienna, Austria.
Frontiers in Immunology
|October 18, 2021
Summary
Video-oculography (VOG) can differentiate anti-IgLON5 disease from progressive supranuclear palsy (PSP). Oculomotor function assessment aids early diagnosis, crucial for therapeutic implications in neuroinflammatory and neurodegenerative conditions.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Anti-IgLON5 disease presents with neuroinflammation and neurodegeneration, mimicking neurodegenerative diseases.
- Early diagnosis and differentiation are critical for effective treatment of anti-IgLON5 disease.
Purpose of the Study:
- Investigate oculomotor function as a key differentiator between anti-IgLON5 disease and neurodegenerative disorders.
- Assess the utility of video-oculography (VOG) in distinguishing anti-IgLON5 disease from progressive supranuclear palsy (PSP).
Main Methods:
- Examined ocular motor and vestibular function in four anti-IgLON5 disease patients.
- Utilized video-oculography (VOG) and a rotational chair system.
- Compared data with ten age-matched PSP patients and healthy controls (CON).
Main Results:
- Anti-IgLON5 disease patients showed distinct saccade velocity and accuracy compared to PSP.
- Square wave jerks (SWJ) and supranuclear gaze palsy were present in PSP but not anti-IgLON5 disease.
- Nystagmus, smooth pursuit, VOR, and VOR suppression reliably differentiated the conditions.
Conclusions:
- Video-oculography (VOG) is a valuable tool for differentiating anti-IgLON5 disease from PSP in clinical neurophysiology.
- VOG may be particularly useful for suspected PSP cases lacking typical Parkinsonian features.
- Further trials are needed to establish oculomotor function as a biomarker for anti-IgLON5 disease.
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