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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: Jun 25, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Facilitating implementation of organs-on-chips by open platform technology.

Anke R Vollertsen, Aisen Vivas, Berend van Meer

¹BIOS Lab on a Chip Group, MESA+ Institute for Nanotechnology, Max Planck Institute for Complex Fluid Dynamics, University of Twente, Enschede, the Netherlands.

Biomicrofluidics

|October 18, 2021

Summary

Standardizing organ-on-chip (OoC) and multi-organs-on-chip (MOoC) systems is crucial for drug discovery and personalized medicine. An open platform with standardized interfaces will improve usability and interoperability, accelerating adoption in research and industry.

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Related Experiment Videos

Last Updated: Jun 25, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Area of Science:

Biotechnology
Drug Discovery
Personalized Medicine

Background:

Organ-on-chip (OoC) and multi-organs-on-chip (MOoC) systems show promise for drug discovery, disease modeling, and personalized medicine.
Current academic OoC devices often lack user-friendliness and scalability, while commercial options lack complexity and interoperability.
Researchers face limitations when combining chips from different suppliers for MOoC systems due to incompatibility.

Purpose of the Study:

To define the concept of an open platform for OoCs from a technical standpoint.
To highlight the necessity of standardization for broader acceptance and application of OoC and MOoC technologies.
To emphasize the importance of multi-stakeholder involvement in developing and implementing open OoC platforms.

Main Methods:

This perspective article defines an open platform concept for OoCs.
It discusses the technical requirements for standardized interfacing and user-friendly operation.
It analyzes the need for collaboration between academia and industry.

Main Results:

Standardization of OoC and MOoC systems is essential for widespread adoption.
An open platform with standardized interfaces can address current limitations in usability and interoperability.
Involving diverse stakeholders is key to successful implementation and acceptance.

Conclusions:

Implementing standards in OoC and MOoC design and operation will accelerate their use in research and industry.
An open platform approach, balancing standardization with proprietary development, is proposed.
Collaborative development involving industry and academia is critical for the future of OoC technology.