Related Experiment Video
Updated: Oct 16, 2025
Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
Published on: January 12, 2024
Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
Seyedeh Maryam Hosseini1, Mojtaba Abrishami1, Elham Barashki1
1Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Purpose:
Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. Case Presentation. A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy.
Conclusion:
There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.
