Intrapleural Tenecteplase for Complicated Parapneumonic Pleural Effusion
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Updated: Oct 16, 2025

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Husain Kadhem1, Kannan Sridharan2, Naser Naser1
1Department of Internal Medicine, Salmaniya Medical Complex, Manama, Bahrain.
Abstract:
Intrapleural thrombolytics have shown promising results in complicated parapneumonic pleural effusions reducing the need for surgical interventions. Until now, studies have evaluated primarily streptokinase, urokinase, and recently, alteplase. In this case series, we share our experience with tenecteplase-a tissue-specific plasminogen activator in 15 patients. We observed that tenecteplase is effective in 14/15 (93.3%) of our patients, and none of them had any bleeding episodes.
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