A Rare Case of Gastrointestinal Mucormycosis

Jasneet Kaur1, Upinder Singh1, Uma Pradhan2

  • 1Department of Pathology, Genomics Laboratory, New Delhi, IND.

Cureus
|October 18, 2021
PubMed

Insights

Gastrointestinal mucormycosis (GIM) is a rare, life-threatening infection. This case highlights GIM occurring after typhoid infection, even without typical risk factors, emphasizing the need for vigilance.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Mycology

Background:

  • Gastrointestinal mucormycosis (GIM) is a rare, angio-invasive fungal infection.
  • Typical risk factors include immunosuppression and metabolic derangement.
  • Ileocecal mucormycosis often presents with classical risk factors.

Observation:

  • Prolonged hospitalization can mask GIM's clinical presentation.
  • Association between mucormycosis and typhoid infection is uncommon.
  • This case involved invasive ileal mucormycosis following typhoid.

Findings:

  • The patient presented with invasive ileal mucormycosis.
  • The infection occurred as a sequel to typhoid infection.
  • Typical risk factors for mucormycosis were absent in this patient.

Implications:

  • This case underscores the importance of considering GIM in patients with typhoid, even without apparent risk factors.
  • It highlights the diagnostic challenge posed by atypical presentations of GIM.
  • Further research may be needed to understand the link between typhoid and GIM.

Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
298
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
181
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
968
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
73.0K
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
812