Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Acute Pharyngitis

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:

Tonsillitis II: Management

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping the Global Research Landscape of Stress Fractures in Athletes.

Orthopedic reviews·2026

Same author

The Trust-Behavior Paradox in Orthopedic Care: A National Survey of Care-Seeking, Misinformation, and Non-Physician Information Sources.

Orthopedic reviews·2026

Same author

Postoperative Pulmonary Complications Following Craniotomy: A 5-Year ACS-NSQIP Analysis of Risk Factors for Pneumonia, Unplanned Intubation, and Prolonged Ventilation.

The Journal of craniofacial surgery·2026

Same author

Modified SIRS Criteria for Patients ≥ 65 Years with Addition of Altered Mental Status and Reduced Heart Rate for Atrioventricular Nodal Blockers.

The western journal of emergency medicine·2026

Same author

The 5-item Modified Frailty Index is a Predictor of Pulmonary Complications in Total Knee Arthroplasty.

Orthopedic reviews·2026

Same author

Fear of diagnosis as a barrier to the screening and diagnosis of breast cancer.

Breast cancer (Tokyo, Japan)·2026

Search research articles

Related Experiment Video

Updated: Oct 16, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis Presenting as Uvulitis.

Lilly Nguyen¹, Thor S Stead², Carlos Lopez Ortiz^3,4,5

¹Emergency Medicine, Trinity Preparatory School, Winter Park, USA.

|October 18, 2021

Summary

A young man experienced severe airway narrowing due to uvular swelling after eating peanut butter, unaware of any allergies. Prompt treatment with epinephrine, diphenhydramine, and methylprednisolone successfully resolved the life-threatening anaphylaxis.

Keywords:

airway emergency allergy and anaphylaxis anaphylaxis emergency medicine uvulitis

More Related Videos

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Related Experiment Videos

Last Updated: Oct 16, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Area of Science:

Allergy and Immunology
Emergency Medicine
Otolaryngology

Background:

Anaphylaxis is a severe, potentially life-threatening allergic reaction.
Uvular swelling can rapidly compromise the airway, necessitating urgent medical intervention.
Peanut allergy is a common cause of anaphylaxis, even in individuals unaware of their sensitivity.

Observation:

A young male presented with acute uvular edema and significant airway narrowing upon waking.
The patient had consumed peanut butter the previous night without prior knowledge of a peanut allergy.
Symptoms developed rapidly, indicating a severe systemic allergic reaction.

Findings:

The uvular swelling and airway compromise were successfully managed with a combination of epinephrine, diphenhydramine, and methylprednisolone.
This case highlights the potential for delayed or unrecognized food allergies to trigger severe anaphylactic events.
Rapid administration of appropriate emergency medications is crucial for reversing life-threatening anaphylaxis.

Implications:

Clinicians should consider anaphylaxis in cases of unexplained acute upper airway obstruction, even without a known allergy history.
Early recognition and prompt treatment of anaphylaxis are critical for patient survival and preventing long-term complications.
This case underscores the importance of patient education regarding food allergies and the availability of emergency treatments like epinephrine auto-injectors.