A Case of Infiltrative Hepatocellular Carcinoma With Vascular Invasion Into the Heart
Related Experiment Video
Updated: Oct 16, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
Chimaobi M Anugwom1,2, Johnstone Kayandabila3, Siobhan Flanagan4
1Gastroenterology, Health Partners Digestive Care, St. Paul, USA.
Insights
Hepatocellular carcinoma (HCC) is a global health issue, particularly in low-resource nations. This case highlights a rare HCC complication in untreated hepatitis B virus infection, stressing the need for better screening in Sub-Saharan Africa.
Area of Science:
- Hepatology
- Oncology
- Infectious Diseases
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide.
- Hepatitis B virus (HBV) infection is a primary risk factor for HCC.
- Limited screening strategies exacerbate HCC burden in low-resource settings.
Observation:
- A rare complication of newly diagnosed HCC was observed.
- The patient had a history of untreated hepatitis B virus (HBV) infection.
- The case occurred in a low-resource country within Sub-Saharan Africa.
Findings:
- The study details a rare complication associated with newly diagnosed HCC.
- The complication arose in the context of untreated chronic hepatitis B virus infection.
- This case underscores diagnostic and screening challenges in specific regions.
Implications:
- Improving HCC screening strategies is crucial for early diagnosis.
- Enhanced diagnostic approaches are needed in Sub-Saharan Africa.
- Addressing HBV infection is vital for reducing HCC incidence and mortality.
Abstract:
Hepatocellular carcinoma (HCC) represents a major cause of morbidity and mortality in the world, but this problem is especially significant in low-resource countries where HCC screening recommendations and strategies are limited. We describe a rare complication of newly diagnosed HCC in a patient with untreated hepatitis B virus (HBV) infection, underscoring the importance of improving screening strategies and promoting early diagnosis of HCC in Sub-Saharan Africa.
More Related Videos
08:17The In Ovo Chick Chorioallantoic Membrane CAM Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma
Published on: October 9, 2015
10:16Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds
Published on: June 6, 2015
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy II: Dilated Cardiomyopathy
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Heart Failure II: Pathophysiology
Cardiomyopathy I: Introduction and Classification