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Two Different Clinical Presentations of Acute Limb Ischemia Caused by Acute Thrombotic Events in COVID-19

Yudistira P Santosa1, Angelina Yuwono1

  • 1Department of Internal Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, IDN.

Cureus
|October 18, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coagulopathy, leading to acute limb ischemia (ALI) in COVID-19 patients. This case series highlights ALI as a critical vascular complication in severe COVID-19 infections.

Area of Science:

  • Vascular Surgery
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • Coagulopathy, a prothrombotic state, is a common complication in severe COVID-19.
  • Hyperinflammation, endotheliitis, and immobility are implicated in COVID-19-associated coagulopathy.

Observation:

  • Two middle-aged male patients with COVID-19 presented with acute limb ischemia (ALI).
  • The first patient developed ALI 16 days post-COVID-19 diagnosis.
  • The second patient presented with sudden lower limb discoloration, with COVID-19 diagnosed during evaluation.

Findings:

  • Acute limb ischemia (ALI) is a significant arterial thrombosis manifestation in COVID-19.
  • COVID-19 infection can precipitate severe thrombotic events, including ALI.
  • Prompt diagnosis and management of ALI are crucial in COVID-19 patients.

Implications:

  • This highlights the importance of recognizing ALI as a potential complication of COVID-19.
  • Vascular surgeons and critical care physicians should consider COVID-19 in patients presenting with ALI.
  • Early identification and treatment of thrombotic complications may improve outcomes for severe COVID-19 patients.

Keywords:
acute limb ischemiaarterial thrombosiscovid-19hypercoagulable statethrombosis

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