Association Between Helicobacter pylori Infection and Serum Iron Profile
Gehna Kishore1, Mishal Ejaz2, Jatender Kumar1
1Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.
Cureus
|October 18, 2021
Summary
Helicobacter pylori infection is linked to lower serum iron and total iron-binding capacity (TIBC). This study found higher ferritin levels in patients with H. pylori, suggesting a connection to iron metabolism.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Hematology
Background:
- Helicobacter pylori (H. pylori) is a major cause of upper gastrointestinal diseases.
- Research on the association between H. pylori and iron deficiency anemia (IDA) is limited.
- This study investigates the relationship between H. pylori infection and iron stores.
Purpose of the Study:
- To determine the association between H. pylori infection and serum levels of total iron-binding capacity (TIBC), serum iron, and ferritin.
- To explore the impact of H. pylori on iron metabolism and the risk of iron deficiency.
Main Methods:
- A case-control study involving 300 H. pylori-positive patients and 300 controls was conducted in Pakistan.
- H. pylori infection was confirmed using Giemsa-stained gastric biopsy specimens.
- Serum ferritin, serum iron, and TIBC levels were measured in all participants.
Main Results:
- Participants with H. pylori infection had significantly lower mean serum iron levels (110.72 ± 28.38 ug/dL) compared to controls (162.5 ± 21.18 ug/dL; p<0.0001).
- Serum ferritin levels were significantly higher in the H. pylori group (536.82 ± 117.0 ng/dL) than in the control group (391.31 ± 101.54 ng/dL; p<0.0001).
- TIBC levels were also found to be lower in patients with H. pylori infection.
Conclusions:
- H. pylori infection is associated with lower serum iron and TIBC levels.
- Elevated ferritin levels in H. pylori-infected individuals warrant further investigation into iron dysregulation.
- The findings suggest a potential link between H. pylori and altered iron homeostasis, possibly contributing to iron deficiency.
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