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The Genomic Landscape of HIV-Associated Plasmablastic Lymphoma
1Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Abstract:
A combined whole-exome and targeted sequencing study of 110 cases of human immunodeficiency virus-associated plasmablastic lymphomas revealed a distinct landscape of genetic lesions for this lymphoma entity, including a particular role of mutations in STAT3 and other members of the JAK-STAT signaling pathway, and of the RAS family in its pathogenesis. See related article by Liu et al., p. 112.
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