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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Role of Hematopoietic Growth Factors01:28

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Overview of Hematopoiesis01:20

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
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Erythropoiesis01:14

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Updated: Oct 16, 2025

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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Epitranscriptomics in Hematopoiesis and Hematologic Malignancies.

Margalida Rosselló-Tortella1,2, Gerardo Ferrer1,3, Manel Esteller1,4,5,6

  • 1Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.

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Epitranscriptomic modifications are crucial for hematopoietic cell development and function. Alterations in these RNA marks are implicated in blood cancers, driving novel therapeutic strategies.

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Hematology

Background:

  • The field of epitranscriptomics studies chemical modifications on RNA molecules.
  • While many RNA modifications exist, their biological roles and associated enzymes are not fully understood.
  • Key epitranscriptomic marks include pseudouridine, N6-methyladenosine (m6A), and A-to-I editing.

Purpose of the Study:

  • To explore the role of the epitranscriptome in normal hematopoiesis and hematologic malignancies.
  • To highlight the therapeutic potential of targeting RNA modifications in blood disorders.

Main Methods:

  • Review of emerging knowledge on epitranscriptomics in hematopoiesis.
  • Analysis of the involvement of RNA modifications in normal and malignant blood cell development.

Main Results:

  • RNA modifications are essential for proper hematopoietic cell development.
  • Aberrant epitranscriptomic patterns are associated with the development and progression of hematologic malignancies.
  • These findings support the development of novel therapeutic strategies targeting the epitranscriptome.

Conclusions:

  • The epitranscriptome plays a critical role in both normal and malignant hematopoiesis.
  • Targeting epitranscriptomic pathways presents a promising avenue for novel cancer therapies.