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Updated: Oct 16, 2025

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Promiscuous Structural Variants Drive Myeloma Initiation and Progression.

P Leif Bergsagel1, W Michael Kuehl2

  • 1Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona.

Blood Cancer Discovery
|October 18, 2021
PubMed
Summary

This study reveals that structural genomic variants, particularly involving the immunoglobulin heavy chain and MYC loci, drive multiple myeloma initiation and progression. It also uncovers numerous genomic factors contributing to the disease's complexity.

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