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Updated: Oct 16, 2025

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Advanced biotechnology-assisted precise sonodynamic therapy.

Yi Zhang1, Xiangqian Zhang2,3, Huocheng Yang1

  • 1Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China. sunyaogbasp@mail.ccnu.edu.cn.

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Summary
This summary is machine-generated.

Sonodynamic therapy (SDT) offers superior deep-seated tumor ablation compared to photodynamic therapy due to deeper light penetration and unique toxicity mechanisms. This review covers imaging-guided SDT, sonosensitizer design, and combination therapies for enhanced cancer treatment.

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Nanotechnology

Background:

  • Photodynamic therapy (PDT) is limited by light penetration depth and reactive oxygen species (ROS) toxicity.
  • Sonodynamic therapy (SDT) utilizes ultrasound for deeper tissue penetration and offers alternative toxicity mechanisms.
  • SDT shows significant preclinical and clinical potential for deep-seated tumor ablation.

Purpose of the Study:

  • To review advancements in imaging-guided sonodynamic therapy.
  • To summarize sonosensitizer design strategies for tumor microenvironment modulation.
  • To explore combination therapies for improved sonodynamic treatment outcomes.

Main Methods:

  • Review of recent clinical trials and preclinical studies on SDT.
  • Analysis of sonosensitizer design principles and structure-activity relationships.
  • Discussion of multimodal therapeutic strategies combined with SDT.

Main Results:

  • Imaging-guided SDT enables precise treatment selection and real-time monitoring.
  • Novel sonosensitizer designs enhance therapeutic efficacy through tumor microenvironment targeting.
  • Combination of SDT with chemotherapy, immunotherapy, and other modalities improves treatment outcomes.

Conclusions:

  • Sonodynamic therapy presents a promising approach for deep-seated tumor treatment.
  • Personalized SDT strategies, including advanced sonosensitizer design and combination therapies, are crucial for future cancer treatment.
  • Further research into SDT holds potential for treating various diseases beyond cancer.