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Updated: Oct 16, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
A case of chronic systemic capillary leak syndrome (SCLS) exacerbated during SARS-CoV2 infection
A Concistrè1, F Alessandri, E Rosato
1Department of Translational and Precision Medicine, University "Sapienza", Rome, Italy. claudio.letizia@uniroma1.it.
Abstract:
Systemic capillary leak syndrome (SCLS) is a very rare and lethal disease characterized by hemoconcentration and hypoalbuminemia caused by reversible plasma extravasation. The underlying cause for SCLS remains largely unknown and acute treatment has remained mainly supportive. Prophylaxis with intravenous immunoglobulin (IVIG) has been shown to successfully prevent further episodes in affected patients. We reported a case of SCLS in a patient who presented to our hospital with COVID-19 and developed profound shock.
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