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Osteoclasts adapt to physioxia perturbation through DNA demethylation

Keizo Nishikawa1,2,3, Shigeto Seno4, Toshitada Yoshihara5

  • 1Laboratory of Cell Biology and Metabolic Biochemistry, Department of Medical Life Systems, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.

EMBO Reports
|October 18, 2021
PubMed
Summary

Cellular oxygen levels impact bone cells. Researchers found that ten-eleven translocation (TET) enzymes act as oxygen sensors, regulating osteoclast formation in live mice.

Keywords:
bone metabolismepigenetic regulationintravital imagingosteoclastoxygen

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