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Related Experiment Video

Updated: Oct 16, 2025

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

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Published on: July 25, 2025

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A Modified Surgical Technique for Submacular Injection.

Avi Ohayon, Shulamit Schwartz, Anat Loewenstein

    Ophthalmic Surgery, Lasers & Imaging Retina
    |October 18, 2021
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a modified surgical technique for submacular injections, utilizing a viscous fluid control system for treating submacular hemorrhage and macular holes effectively.

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    Area of Science:

    • Ophthalmology
    • Retinal Surgery
    • Surgical Techniques

    Background:

    • Submacular hemorrhage (SMH) and persistent macular holes present significant challenges in retinal surgery.
    • Current techniques may have limitations in addressing these complex conditions.

    Purpose of the Study:

    • To describe a modified, simple surgical technique for submacular injections.
    • To evaluate the efficacy of this technique in treating SMH, subfoveal perfluorocarbon (PFC) bubbles, and persistent full-thickness macular holes (FTMH).

    Main Methods:

    • The technique involves pars plana vitrectomy and a viscous fluid control (VFC) system.
    • Semi-automatic subretinal injection of tissue plasminogen activator (tPA), bevacizumab, and air for SMH.
    • Subretinal balanced salt solution (BSS) injection for PFC bubbles or FTMH.

    Main Results:

    • Successful application in five patients with SMH, two with subfoveal PFC bubbles, and one with FTMH.
    • SMH clearance and displacement were achieved without complications using the VFC system.
    • Subretinal BSS injection proved effective for PFC bubble removal and FTMH closure.

    Conclusions:

    • The modified surgical technique with semi-automatic subretinal injection is effective for SMH management.
    • Subretinal BSS injection is a viable option for subfoveal PFC bubbles and persistent FTMH.
    • This approach offers a promising solution for challenging macular conditions.