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Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New
Juan Bautista Menendez-Gonzalez1, Jonathan Hoggatt2
1Center for Cancer Research, Center For Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA.
Stem Cell Reviews and Reports
|October 18, 2021
Summary
Hematopoietic stem cell mobilization enhances stem cell collection for transplantation. This process offers new avenues for studying stem cell diversity and improving gene therapies for genetic diseases.
Area of Science:
- Hematology
- Stem Cell Biology
- Translational Medicine
Background:
- Hematopoietic stem cells (HSCs) naturally migrate from bone marrow to peripheral blood.
- Pharmacologic agents can enhance this migration, a process known as HSC mobilization.
- Mobilized HSCs are crucial for transplantation and emerging therapeutic strategies.
Purpose of the Study:
- To review the current landscape of HSC mobilization.
- To provide an update on recent clinical trials and novel biological regulators of HSC trafficking.
- To explore the potential applications of HSC mobilization in research and therapy.
Main Methods:
- Review of existing literature and clinical trial data on HSC mobilization.
- Analysis of biological mechanisms governing stem cell trafficking.
- Conceptualization of novel applications for HSC mobilization.
Main Results:
- Mobilization is an established method for collecting HSCs for transplantation.
- Recent advancements have elucidated new biological pathways regulating stem cell trafficking.
- Clinical trials are exploring novel agents and strategies for enhanced mobilization.
Conclusions:
- HSC mobilization is a dynamic field with ongoing advancements.
- Mobilization can serve as a tool to investigate HSC heterogeneity.
- This process holds promise for non-toxic conditioning, gene editing, and gene therapy for genetic disorders.
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