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Inflammaging and Cannabinoids.

Babak Baban1, Hesam Khodadadi2, Évila Lopes Salles2

  • 1Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, DCG Center for Excellence in Research, Scholarship and Innovation (CERSI), Augusta University, Augusta, GA, USA; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta, Augusta University, Augusta, GA, USA; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Ageing Research Reviews
|October 18, 2021
PubMed
Summary
This summary is machine-generated.

This study explores inflammaging, a key aspect of aging, and proposes phytocannabinoids as potential therapies to promote healthier aging by regulating the immune system.

Keywords:
AgingCBDCannabinoidsCannabisInflammagingInflammationMicrobiome

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Area of Science:

  • Gerontology
  • Immunology
  • Pharmacology

Background:

  • Aging involves widespread physiological changes impacting all organisms.
  • The immune system is crucial for defense and injury response, and is significantly affected by aging.
  • Immunosenescence describes the aging of the immune system, with inflammaging (chronic, low-grade inflammation) as a central component.

Purpose of the Study:

  • To review the nature of the aging-related inflammaging cycle.
  • To propose phytocannabinoids as immune modulators for therapeutic intervention.
  • To explore the potential of phytocannabinoids in slowing or reversing age-related pathologies.

Main Methods:

  • Literature review on aging, immunosenescence, and inflammaging.
  • Analysis of the reciprocal relationship between the immune system and aging.
  • Exploration of phytocannabinoid mechanisms as immune regulators.

Main Results:

  • Inflammaging is a sustained, low-grade inflammation that exacerbates aging processes.
  • The effects of inflammaging create a detrimental cycle that accelerates further aging.
  • Phytocannabinoids demonstrate potential as immune regulators.

Conclusions:

  • Phytocannabinoids may serve as effective adjunctive therapies for aging.
  • These compounds could help mitigate the adverse effects of inflammaging.
  • Targeting inflammaging with phytocannabinoids may facilitate healthier aging.