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Chalcone embedded polyurethanes as a biomaterial: Synthesis, characterization and antibacterial adhesion
Ponnurengam Malliappan Sivakumar1, Stefania Cometa2, Michele Alderighi2
1Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India; Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
A novel antibacterial copolymer composite film was developed using a dimethylamino-chalcone embedded multiblock copolymer (PCL-PEG). This new biomaterial demonstrates enhanced antibacterial adhesion, offering a promising solution for preventing bacterial colonization.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Antimicrobial Materials
Background:
- Development of advanced biomaterials with inherent antibacterial properties is crucial for preventing implant-associated infections.
- Multiblock copolymers offer tunable properties for various biomedical applications.
- Chalcone derivatives have shown potential antimicrobial activity.
Purpose of the Study:
- To synthesize and characterize a novel antibacterial dimethylamino-chalcone embedded multiblock copolymer (PCL-PEG).
- To evaluate the potential of the developed copolymer composite film as a new biomaterial with antibacterial properties.
Main Methods:
- Synthesis and characterization of the PCL-PEG copolymer and the chalcone compound using FT-IR, NMR (1H, 13C), and SEC.
- Preparation of a 10% copolymer composite film and control copolymer film.
- Analysis of material properties using TGA, DSC, AFM, SEM, and EDAX.
- Assessment of surface properties including roughness (Ra) and hydrophilicity.
- Evaluation of antibacterial adhesion using Colony Forming Unit (CFU) measurement and SEM analysis.
Main Results:
- The copolymer composite film exhibited reduced surface roughness, indicating uniform chalcone distribution.
- The composite film demonstrated increased hydrophilicity compared to the control.
- Significant antibacterial adhesion was observed on the copolymer composite film.
- SEM analysis confirmed reduced bacterial adhesion on the composite film.
Conclusions:
- The synthesized PCL-PEG copolymer composite film possesses effective antibacterial properties.
- The material's improved surface characteristics and hydrophilicity contribute to its antibacterial efficacy.
- This novel copolymer composite film shows potential as an advanced biomaterial for applications requiring antimicrobial activity.
