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Updated: Oct 16, 2025
Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
Synthesis, characterization and in vitro cytocompatibility studies of chitin nanogels for biomedical applications
N Sanoj Rejinold1, Amrita Nair1, M Sabitha1
1Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
Abstract:
In this work we developed biodegradable chitin nanogels (CNGs) of size 65nm by controlled regeneration method and characterized. The CNGs showed higher swelling and degradation in acidic pH. The in vitro cytocompatibility was analyzed on an array of cell lines and cell uptake studies were done by conjugating CNGs with the rhodamine-123 dye (rhodamine-123-CNGs), which showed retention of nanogels inside the cells. Our preliminary studies reveal that these nanogels could be useful for the delivery of drugs, growth factors for drug delivery and tissue engineering.
