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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
Xi-Yao Chen1, Yang Jiao2, Fu-Yang Zhang3
1Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
Military Medical Research
|October 19, 2021
Abstract:
The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.
