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Broadening Diversity in PDAC Trials

    Cancer Discovery
    |October 19, 2021
    PubMed
    Summary

    Common eligibility criteria in simulated pancreatic cancer trials disproportionately exclude Black patients. Alternative criteria were proposed to eliminate this racial imbalance in clinical trial enrollment.

    Area of Science:

    • Oncology
    • Clinical Trial Design
    • Health Equity

    Background:

    • Clinical trials are crucial for advancing cancer treatment.
    • Eligibility criteria can significantly impact patient representation in trials.
    • Existing criteria may inadvertently create disparities in access to investigational therapies.

    Purpose of the Study:

    • To analyze the impact of common eligibility criteria on racial disparities in pancreatic cancer trial enrollment.
    • To propose and evaluate alternative criteria to improve Black patient representation.

    Main Methods:

    • A simulated pancreatic cancer clinical trial was designed.
    • Common eligibility criteria, including infectious comorbidities, were assessed for their impact on Black versus white patient eligibility.

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  • Alternative eligibility criteria were developed and tested for their effect on enrollment balance.

    • Main Results:

    • Infectious comorbidities and other standard criteria disproportionately disqualified Black patients compared to white patients.
    • The proposed alternative eligibility criteria demonstrated the potential to eliminate the observed racial imbalance.
    • Adjusting criteria could significantly enhance diversity in pancreatic cancer research.

    Conclusions:

    • Current eligibility criteria in pancreatic cancer trials contribute to racial disparities.
    • Modifying eligibility criteria is a viable strategy to promote equitable patient enrollment.
    • Future research should focus on refining criteria to ensure inclusive clinical trial participation.