Related Experiment Video

Updated: Oct 16, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
07:31

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

1.3K

Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing

Xiaolong Qi1,2, Xiaoxu Chen3, Jiayin Guo3,4

  • 1Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medicine College, Beijing, China.

Cell Discovery
|October 19, 2021
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

1.6K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.9K

Related Experiment Videos

Last Updated: Oct 16, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
07:31

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

1.3K
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

1.6K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.9K

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

8.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.3K
RNA Editing02:23

RNA Editing

9.3K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.3K

Articles linked to this work by shared authors, journal, and citation graph.

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9.

Animal models and experimental medicine·2025

Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot.

Science advances·2025

Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types.

Cell research·2025

Age-dependent accumulation of mitochondrial tRNA mutations in mouse kidneys linked to mitochondrial kidney diseases.

Nature aging·2025

VIRMA-mediated m6A modification regulates forebrain formation through modulating ribosome biogenesis.

Science advances·2025

Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis.

Nature neuroscience·2025

HMMR+ stromal cells drive human uterine development.

Cell discovery·2026

Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening.

Cell discovery·2026

Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.

Cell discovery·2026

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos.

Cell discovery·2026

Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells.

Cell discovery·2026

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates.

Cell discovery·2026

VAC-Stent as salvage therapy after failed surgical repair and self-expandable metal stent treatment in esophageal perforation.

Revista espanola de enfermedades digestivas·2026

Innovative Solutions for Obesity: Evaluating gastric bypass stents in Postlaparoscopic Sleeve Gastrectomy Weight Management.

Endoscopy international open·2026

Long-Term Outcome After Pulsed Field Ablation for Atrial Fibrillation Across an Atrial Septal Defect Closure Device: A 20-Month Follow-Up Case Report.

Clinical case reports·2026

Balloon-Assisted Maturation in Salvaging Stenosed Arteriovenous Fistulas: A Case Series and Clinical Insights.

Cureus·2026

Cardiomyoplasty: A renaissance of an abandoned technique.

The International journal of artificial organs·2026

Enhancing spatial neglect screening: Preliminary evidence from a modified Baking Tray Test.

Applied neuropsychology. Adult·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us