[Leukocyte-thrombocyte interactions in chronic myeloleukemia and erythremia]

An effect of the leucocytes of patients with chronic myeloproliferative diseases on the formation of cellular microthrombi in vitro was studied. A high degree of correlation between the amount of leucocytes and the rate of mixed cell leucocyte-thrombocyte aggregation was shown. The clinical signs of enhanced leucocyte-thrombocyte interactions in patients were disorders of microcirculation and intravascular microthrombus formation. It was shown that leucocytes could compensate the manifestations of thrombocytopenia and thrombocytopathy in chronic myeloproliferative diseases. The main types of leucocyte-thrombocyte interactions were singled out. An important role of erythrocyte hemolysis in the initiation of leucocyte-thrombocyte contacts was established. It was proposed that an increased amount of leucocytes especially in noticeable "rejuvenation" of their structure, should be regarded as one of the humoral factors of thrombogenicity in chronic myeloproliferative diseases.