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Updated: Oct 16, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
[17-year-old patient with polymorphic premature ventricular contractions]
Christian Wolpert1, Norman Rüb
1Klinik für Innere Medizin, Kardiologie, Nephrologie und internistische Intensivmedizin, Klinikum Ludwigsburg, Posilipostraße 4, 71640, Ludwigsburg, Deutschland. christian.wolpert@rkh-kliniken.de.
Abstract:
A 17-year-old patient with premature ventricular contractions and normal left ventricular function was referred for reablation after an unsuccessful catheter ablation attempt. Holter monitoring demonstrated a high burden of premature ventricular contractions, present throughout the whole recording. The patient reported occasional paralytic attacks; his face had a dysmorphic appearance with a wide distance between the eyes, a caudal insertion of the ears, and a high forehead. These three features resulted in a clinical diagnosis that was confirmed by molecular biology and completely changed the therapeutic strategy.
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