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Related Concept Videos

Sympathetic Signaling01:31

Sympathetic Signaling

1.4K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
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Adrenergic Neurons: Neurotransmission01:27

Adrenergic Neurons: Neurotransmission

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Postganglionic sympathetic fibers (except those supplying the sweat glands) releasing noradrenaline or norepinephrine are called noradrenergic or adrenergic neurons. Noradrenaline, dopamine, adrenaline, or epinephrine are collectively called "catecholamines" as they contain a catechol moiety and an amine side chain. The five stages of neurotransmitter release involve their synthesis, storage, release, reuptake and metabolism.
Synthesis: Catecholamine synthesis requires tyrosine, which...
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Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

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The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
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Adrenergic Receptors (Adrenoceptors): Classification01:27

Adrenergic Receptors (Adrenoceptors): Classification

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Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
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Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

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Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Related Experiment Video

Updated: Oct 16, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

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The Adrenergic Nerve Network in Cancer.

Claire Magnon1

  • 1Laboratory of Cancer and Microenvironment, UMR1274-INSERM/iRCM/IBFJ/DRF/CEA, Université de Paris, Université Paris-Saclay, Paris, France. claire.magnon@inserm.fr.

Advances in Experimental Medicine and Biology
|October 19, 2021
PubMed
Summary
This summary is machine-generated.

The brain and nervous system influence cancer growth through adrenergic signaling. Understanding this nerve circuitry offers new therapeutic strategies for cancer development.

Keywords:
Adrenergic nerve circuitryAdrenergic nerve signalingAdrenergic neuronAutonomic nervous systemCancer neuroscienceCentral nervous systemHypothalamo-pituitary-adrenal axisSympathetic nervous systemSympathoadrenal systemTumor axonogenesisTumor microenvironmentTumor neurogenesis

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In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
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Area of Science:

  • Neuroscience
  • Oncology
  • Cancer Biology

Background:

  • The central and autonomic nervous systems interact to form an adrenergic nerve network that can promote cancer.
  • Local adrenergic sympathetic innervation in tumors affects cancer and stromal cell behavior.
  • The brain contributes to cancer development via dysregulation of the sympathoadrenal system, adrenergic neurons, and the hypothalamo-pituitary-adrenal axis.

Purpose of the Study:

  • To explore the role of the adrenergic nervous system in cancer promotion.
  • To investigate the interplay between the brain, nervous system, and tumor microenvironment.
  • To identify novel therapeutic targets by understanding adrenergic nerve circuitry.

Main Methods:

  • Review of existing literature on neuro-oncology and adrenergic signaling.
  • Analysis of the interaction between neural networks and tumor microenvironments.
  • Exploration of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis in cancer.

Main Results:

  • Adrenergic nerve networks, involving both central and autonomic systems, are implicated in promoting cancer.
  • Brain-mediated dysregulation of the sympathoadrenal system and related pathways influences cancer progression.
  • Tumor microenvironments are modulated by local sympathetic innervation.

Conclusions:

  • Understanding the adrenergic nerve circuitry in the brain and tumors is crucial for elucidating cancer mechanisms.
  • Targeting the neuro-cancer axis presents novel therapeutic opportunities.
  • Further research into the neural control of cancer is warranted.