Related Experiment Video
Updated: Oct 16, 2025
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Acute toxicity and patient-reported symptom score after conventional versus moderately hypofractionated proton
Takashi Iizumi1, Hitoshi Ishikawa2, Yuta Sekino1,3
1Department of Radiation Oncology and Proton Medical Research Center, University of Tsukuba, Tsukuba, Japan.
Introduction:
To confirm the feasibility of hypofractionated proton beam therapy (PBT), we compared the acute adverse event rates and International Prostate Symptom Score (IPSS) in prostate cancer patients treated with hypofractionated versus conventionally fractionated (2.0 Gy relative biological effectiveness (RBE)/fraction) PBT.
Methods:
We reviewed 289 patients with prostate cancer, of whom 73, 100, and 116 patients were treated with 2.0, 2.5, and 3.0 Gy (RBE)/fraction, respectively. The endpoints were acute genitourinary and gastrointestinal toxicities and the IPSS, evaluated up to 6 months after PBT initiation.
Results:
No significant differences were found in acute toxicity rates or the IPSS among the fractionation schedules. Diabetes mellitus, age, and androgen deprivation therapy were not identified as factors associated with the IPSS.
Conclusion:
There were no significant differences in adverse events or quality of life among the three fractionation schedules early after PBT.
