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Updated: Jun 12, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms
Qiangwei Zhou1,2, Pengpeng Guan1,2, Zhixian Zhu1,2
1National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.
Allele-specific DNA methylation (ASM) is crucial for development and disease, yet poorly understood. This study establishes ASMdb, a comprehensive database across 47 species, revealing ASM
Area of Science:
- Epigenetics
- Genomics
- Bioinformatics
Background:
- DNA methylation is a stable epigenetic modification involved in development and disease.
- Allele-specific DNA methylation (ASM) regulates gene expression and is linked to carcinogenesis and development.
- Existing research on ASM functions in disease and development is limited.
Purpose of the Study:
- To establish a comprehensive database of ASM across 47 species.
- To analyze ASM and allele-specific expressed genes (ASEGs) distribution patterns.
- To identify potential ASM-related genes in cancer.
Main Methods:
- Collected and analyzed 4400 BS-Seq and 1598 RNA-Seq datasets from 47 species.
- Developed ASMdb, a comprehensive database for ASM data.
- Performed in-depth ASM distribution and differential methylation analysis in nine cancer types.
Main Results:
- Generated comprehensive data on DNA methylation levels, ASM, and ASEGs.
- Revealed ASM/ASEG distribution patterns across diverse species.
- Identified potential ASM tumor-related genes consistent with known cancer gene alterations.
Conclusions:
- ASMdb is the first comprehensive database for ASM across 47 species.
- The database provides valuable resources for studying ASM functions in development and disease.
- Further research into ASM's role in carcinogenesis and development is warranted.
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