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Updated: Aug 14, 2026

Isolation of Cardiomyocyte Nuclei from Post-mortem Tissue
Published on: July 10, 2012
Primary malignant lymphoma of the heart. Antemortem cytologic diagnosis
Insights
A rare case of primary cardiac lymphoma was diagnosed using cytology. Despite prompt treatment, the patient experienced rapid cardiac failure and succumbed within 15 days, with lymphoma confined to the heart muscle.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary malignant lymphoma of the heart is an extremely rare condition.
- Early diagnosis and treatment are crucial for patient outcomes.
Observation:
- A patient presented with symptoms of pericardial tamponade and ventricular arrhythmias.
- Two-dimensional echocardiography revealed pericardial effusion and impaired left ventricular function.
- Pericardial fluid analysis confirmed the presence of malignant lymphoid cells.
Findings:
- The case involved primary malignant lymphoma of the heart diagnosed via cytology.
- The patient experienced rapidly progressive and intractable cardiac failure.
- Despite chemotherapy and treatment, the patient died within 15 days.
Implications:
- This case highlights the diagnostic challenges and aggressive nature of primary cardiac lymphoma.
- Cytological diagnosis from pericardial fluid can be vital for early detection.
- Further research into effective therapeutic strategies for cardiac lymphoma is warranted.
Abstract:
A case of primary malignant lymphoma of the heart diagnosed cytologically is reported. The patient presented with pericardial tamponade and ventricular arrhythmias and developed rapidly progressive and intractable cardiac failure. Two-dimensional echo-cardiography, which demonstrated the pericardial effusion, showed progressive impairment of the left ventricular contraction. The pericardial fluid contained malignant lymphoid cells. Despite vigorous treatment and chemotherapy, the patient died within 15 days; postmortem examination showed malignant lymphoma confined to the myocardium.

