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Generating Transgenics and Knockouts in Strongyloides Species by Microinjection
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Cestodes in the genomic era.

Laura Kamenetzky1, Lucas L Maldonado2,3, Marcela A Cucher2,3

  • 1iB3, Instituto de Biociencias, Departamento de Fisiología Y Biología Molecular Y Celular, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Biotecnología y Biología traslacional, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. lauka@fbmc.fcen.uba.ar.

Parasitology Research
|October 19, 2021
PubMed
Summary
This summary is machine-generated.

Genomic sequencing reveals cestode parasites have smaller genomes than other animals, with variations between species. This research aids in understanding and controlling cestode-transmitted diseases.

Keywords:
CestodeGenomeParasiteSequencing

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Area of Science:

  • * Genomics and Parasitology: Focuses on the genetic makeup of parasitic flatworms (cestodes).

Background:

  • * Cestodes are significant etiological agents of endemic diseases globally.
  • * Previous research has sequenced genomes of 16 cestode species.

Purpose of the Study:

  • * To review the current status of complete cestode genomes.
  • * To place cestode genomics in a comparative perspective.
  • * To identify genomic features relevant to parasitic adaptation and disease control.

Main Methods:

  • * Comparative genomics analysis of 16 complete cestode genomes.
  • * Integration of gene predictions and transcriptome evidence for protein annotation.
  • * Characterization of chromosome terminal sequences using advanced sequencing technologies.

Main Results:

  • * Cestode genomes are smaller than other animals, with Cyclophyllidea having smaller genomes and less repetitive content than Diphyllobothriidea.
  • * Average cestode genome: 13,753 genes, 6 exons/gene, 41% GC content.
  • * Over 40% of over 5,000 shared cestode proteins have unknown functions; gene losses and reductions observed, potentially linked to parasitic lifestyle.

Conclusions:

  • * Cestode genomes exhibit unique characteristics, including smaller sizes and reduced gene families, reflecting their parasitic nature.
  • * Advanced sequencing technologies have enabled detailed characterization of cestode chromosomes.
  • * Further multidisciplinary research and technological advancements are crucial for controlling cestode-borne diseases.