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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

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Intrapartum antibiotics and childhood asthma and allergic rhinitis: a retrospective cohort study

M Richards1, J Ferber2, E Swor3

  • 1School of Public Health, University of Nevada, Reno, NV, USA.

BJOG : an International Journal of Obstetrics and Gynaecology
|October 19, 2021
PubMed

Insights

Intrapartum antibiotics (IABX) exposure is not a strong predictor of childhood asthma or allergic rhinitis. This retrospective cohort study found minimal association between IABX and these common childhood conditions.

Area of Science:

  • Pediatric Allergy and Immunology
  • Obstetrics and Gynecology
  • Public Health Research

Background:

  • Intrapartum antibiotics (IABX) use has increased significantly.
  • Potential links between IABX and childhood allergic diseases require investigation.

Purpose of the Study:

  • To evaluate the association between intrapartum antibiotic exposure and the development of asthma and allergic rhinitis in children.
  • To assess these associations at ages 6, 8, and 10 years.

Main Methods:

  • Retrospective cohort study utilizing data from Kaiser Permanente Northern California.
  • Modified Poisson regressions were used to estimate risk ratios for IABX and outcomes.
  • Analysis covered two birth cohorts: 1997-2004 and 2005-2012.

Main Results:

  • IABX use rose from 4% in 1997 to 49% in 2011, while asthma and allergic rhinitis incidence remained stable.
  • Risk ratios for asthma and allergic rhinitis associated with IABX were generally close to the null.
  • Slightly elevated risk ratios were observed in some analyses, particularly for asthma in the later cohort.

Conclusions:

  • Intrapartum antibiotic exposure does not appear to be a significant predictor of childhood asthma or allergic rhinitis.
  • Further research may explore subtle associations or specific subgroups.
Abstract

Keywords:
Allergic rhinitisasthmaintrapartum antibiotics

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