Effect of Angiotensin-I Converting Enzyme Gene Insertion/Deletion Polymorphism on genome instability in children

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Dina Alexandrovna Petrashova1, S N Kolomeichuk2,3

  • 1Kola Science Centre, Russian Academy of Sciences.

Klinicheskaia Laboratornaia Diagnostika
|October 19, 2021
PubMed

Insights

Childhood arterial hypertension risk is high in the Far North. Genetic analysis of the ACE gene

Area of Science:

  • Pediatrics
  • Genetics
  • Environmental Health

Background:

  • Arterial hypertension in children poses significant health risks, particularly in remote regions like the Far North.
  • Early, accessible diagnostic methods for childhood pathologies are crucial.
  • The angiotensin-converting enzyme (ACE) gene's in/del polymorphic marker, specifically the DD genotype, is linked to cardiovascular disease risk.

Purpose of the Study:

  • To investigate the association between the ACE gene's in/del polymorphic marker and cellular changes in schoolchildren.
  • To explore the potential of this genetic marker as an early indicator of health risks in adolescents.

Main Methods:

  • Utilized buccal micronucleus cytome assay and genetic analysis.
  • Examined 77 schoolchildren aged 15-17 from Apatity.
  • Assessed frequency of micronuclei and karyopycnosis in relation to ACE gene variants.

Main Results:

  • Children carrying the D allele of the ACE gene showed a trend towards increased micronuclei frequency.
  • Homozygous I/I variant carriers exhibited significantly higher karyopycnosis rates compared to D allele carriers.
  • The ACE gene's in/del polymorphic marker correlated with apoptotic cellular changes in the studied children.

Conclusions:

  • The in/del polymorphic marker of the ACE gene is associated with early apoptotic changes in children's cells.
  • This marker shows potential for predicting genome destabilization processes in the early stages of human development.
  • Genetic screening of the ACE gene may aid in identifying children at risk for future health issues.

Keywords:
ArcticBuccal micronucleus cytome assayangiotensin converting enzymebuccal cellsgenetic polymorphismhigh latitudemicronucleus

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