Prostaglandin D2 release by endometrium and myometrium

Prostaglandin D2 (PGD2) release was studied using a superfusion technique in endometrium and myometrium obtained at hysterectomy from 36 women with measured menstrual blood loss (range 4-840 ml). PGD2 was produced by both tissues with greater rates from endometrium. Cyclical changes in release were found only in the endometrium with increased rates during menstruation and the mid-luteal phase. In the myometrium the highest release rates were present during menstruation at the start of the superfusion. No significant correlation was found between menstrual blood loss and endometrial or myometrial PGD2 release.