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Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination
Published on: July 4, 2007
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Global dengue importation: a systematic review
Xiao Wei Sylvia Gwee1,2, Pearleen Ee Yong Chua1,2, Junxiong Pang3,4,5
1Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
BMC Infectious Diseases
|October 20, 2021
Summary
Dengue importation is a growing global health threat, primarily originating from Asia. This risk is amplified by climate change and globalization, increasing the potential for outbreaks in non-endemic areas.
Area of Science:
- Epidemiology
- Global Health
- Infectious Diseases
Background:
- Globalization facilitates the international spread of dengue, posing a significant threat to global health.
- Limited data exists on the primary geographical sources of dengue importation and the global risk of outbreaks.
- This study addresses the need for a comprehensive review of dengue importation sources and outbreak potential worldwide.
Purpose of the Study:
- To systematically review and analyze the global geographical sources of dengue importation.
- To assess the worldwide risk and patterns of dengue importation and subsequent outbreaks.
- To specifically examine importation into the United States of America and Europe.
Main Methods:
- A systematic review adhering to Cochrane's PRISMA guidelines was performed.
- Data was collected from PubMed, EMBASE, and Scopus for articles published up to December 31, 2019.
- Analysis focused on laboratory-confirmed imported dengue cases and their reported geographical origins.
Main Results:
- Out of 3762 articles, 210 met eligibility criteria, detailing 14,972 imported dengue cases.
- Asia was the predominant source of imported dengue cases globally (76.3%).
- Significant importation into the U.S. originated from the Americas (55.3%) and Asia (34.7%), while Europe's cases were mainly from Asia (66.0%) and the Americas (21.9%).
Conclusions:
- Dengue importation presents a substantial global health security threat, particularly in regions susceptible to outbreaks.
- Expanding Aedes mosquito populations due to global warming and globalization exacerbate the risk of dengue importation.
- Non-endemic regions with susceptible populations face a high potential for dengue outbreaks.
