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Radiomics in Antineoplastic Agents Development: Application and Challenge in Response Evaluation.
1Department of Radiology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.
Summary
Radiomics offers a promising solution for evaluating new cancer drugs, overcoming limitations of current imaging methods. This technique analyzes complex imaging data to predict treatment response and patient outcomes.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
- Artificial Intelligence
Background:
- Advancements in antineoplastic agents and prolonged survival present new challenges and opportunities in radiological practice.
- Radiological imaging (CT, MRI, PET) is crucial for assessing antineoplastic drug efficacy.
- Current response evaluation relies heavily on morphological criteria (RECIST), which struggle with diverse drug-induced imaging signs.
Purpose of the Study:
- To introduce the fundamental concepts of radiomics.
- To review the current state of radiomics research in oncology.
- To explore radiomics' potential in predicting treatment response and patient prognosis.
Main Methods:
- Review of existing literature on radiomics applications in cancer treatment evaluation.
- Analysis of radiomics' role in predicting molecular biomarkers, treatment response, and prognosis.
- Discussion of challenges and future directions for radiomics in clinical trials.
Main Results:
- Radiomics shows potential as a surrogate for evaluating anti-tumor treatment efficacy.
- Highlights radiomics' application in predicting molecular biomarkers, treatment response, and prognosis.
- Identifies key obstacles and future research avenues for clinical radiomics investigations.
Conclusions:
- Radiomics presents a significant opportunity to enhance radiological practice in the era of novel antineoplastic agents.
- The technique offers a powerful tool for more accurate and comprehensive treatment response evaluation.
- Further research is needed to overcome current obstacles and fully realize radiomics' clinical potential.
