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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Positive Attributes of Anti-TERT CD4 T-Helper Type 1 Immune Responses in Melanoma
Eduardo Nagore1, Amaya Virós2, Rajiv Kumar3
1Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain.
Abstract:
Nardin et al's (2021) study on melanoma reports anti-TERT CD4 T helper type (Th) 1 responses in more than half of patients. Besides indicating a trend for improved survival, increased anti-TERT CD4 Th1 responses predicted better outcomes for patients treated with immune checkpoint inhibitors. Thus, harnessing systemic anti-TERT CD4 Th1 responses together with tumor-specific elevation of telomerase can potentially open new avenues for biomarkers and treatment in melanoma.
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