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MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and

Cong Huang1, Weilong Zhong2, Xuanyao Ren3

  • 1Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, China.

Cell Death & Disease
|October 20, 2021
PubMed

Insights

MicroRNA miR-193b-3p is downregulated in psoriasis, suppressing keratinocyte proliferation and inflammation by targeting ERBB4. Restoring miR-193b-3p levels offers a potential therapeutic strategy for psoriasis.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is an auto-inflammatory skin disease involving keratinocyte activation and immune dysregulation.
  • MicroRNAs (miRNAs) are implicated in psoriasis pathogenesis, with miR-193b-3p downregulation noted.
  • The exact role and mechanism of miR-193b-3p in psoriasis remain to be fully elucidated.

Purpose of the Study:

  • To investigate the function and mechanism of miR-193b-3p in psoriasis.
  • To explore the relationship between miR-193b-3p and psoriasis severity.
  • To identify potential therapeutic targets for psoriasis based on miRNA regulation.

Main Methods:

  • Confirmed miR-193b-3p downregulation in patient samples and disease models.
  • Assessed the impact of miR-193b-3p on keratinocyte proliferation and inflammatory pathways (STAT3, NF-κB).
  • Utilized in vivo models (agomiR/antagomiR) and bioinformatics/luciferase assays to identify miR-193b-3p targets.

Main Results:

  • miR-193b-3p was downregulated in psoriasis patients and models, correlating negatively with PASI scores.
  • miR-193b-3p suppressed keratinocyte proliferation and inflammation via STAT3 and NF-κB pathways.
  • ERBB4 was identified as a direct target of miR-193b-3p, mediating its effects on keratinocytes.

Conclusions:

  • The miR-193b-3p-ERBB4 axis is crucial in psoriatic keratinocyte hyperproliferation and inflammation.
  • miR-193b-3p acts as a negative regulator of keratinocyte activation by targeting ERBB4.
  • This study reveals a novel miRNA-based mechanism and potential therapeutic avenue for psoriasis.

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