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Subcutaneous Sweet Syndrome Presenting as Cellulitis in a Pregnant Female
1Dermatology, Southern Illinois University School of Medicine, Springfield, USA.
Cureus
|October 20, 2021
Summary
This case study details subcutaneous Sweet syndrome, a rare pregnancy condition initially misdiagnosed as cellulitis. Prompt steroid treatment led to rapid symptom resolution, confirming the diagnosis through skin biopsy.
Area of Science:
- Dermatology
- Rheumatology
- Obstetrics
Background:
- Sweet syndrome is an acute febrile neutrophilic dermatosis.
- Subcutaneous Sweet syndrome is a rare variant affecting deeper skin layers.
- Pregnancy is an uncommon demographic for this condition.
Observation:
- A pregnant patient presented with a progressive rash initially treated as cellulitis.
- Outpatient antibiotic therapy failed to resolve symptoms, leading to hospitalization.
- Nausea and loss of appetite accompanied the worsening rash.
Findings:
- Multidisciplinary consultation (Infectious Disease, Rheumatology, Dermatology) was initiated.
- Skin biopsies were performed for diagnostic confirmation.
- Intravenous steroid therapy resulted in rapid clinical improvement, preceding biopsy results.
Implications:
- Biopsy revealed a dense neutrophilic infiltrate in subcutaneous fat, confirming subcutaneous Sweet syndrome.
- The rarity of this condition in pregnant patients highlights diagnostic challenges.
- Early recognition and appropriate treatment, potentially including corticosteroids, are crucial.
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