Acquired Dermal Macular Hyperpigmentation: An Update

Area of Science:

• Dermatology
• Pathology

Background:

• Acquired dermal macular hyperpigmentation (ADMH) encompasses conditions like lichen planus pigmentosus and Riehl's melanosis.
• These disorders present with pigmented macules and interface dermatitis, often lacking a clear inflammatory phase.
• Their nomenclature and etiology have been debated, complicating research and treatment.

Purpose of the Study:

• To provide a comprehensive review of recent advancements in Acquired Dermal Macular Hyperpigmentation (ADMH).
• To consolidate understanding of related conditions under a single, unifying term.
• To facilitate future research and therapeutic trials for ADMH.

Main Methods:

• Literature review of recent studies on ADMH and related conditions.
• Analysis of clinicopathological similarities and differences.
• Synthesis of current understanding regarding nomenclature and etiology.

Main Results:

• ADMH is proposed as an umbrella term for previously distinct disorders.
• Shared features include pigmented macules and interface dermatitis with pigment incontinence.
• Recent consensus supports a unifying nomenclature for research and clinical trials.

Conclusions:

• A unified approach to ADMH is crucial for advancing research and treatment.
• Understanding recent advances is key to managing these challenging pigmentary conditions.
• ADMH facilitates a clearer framework for studying and treating lichen planus pigmentosus, Riehl's melanosis, and ashy dermatosis.