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Long-term outcomes after revascularization and medical therapy in premature coronary artery disease for

Farbod Ebadi Fard Azar1, Ali Aboutorabi2, Mohammad Afrouzi2

  • 1Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran.

Journal of Education and Health Promotion
|October 20, 2021
PubMed

Insights

This study compares long-term outcomes for premature coronary artery disease patients treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or medical therapy (MT). Findings inform cost-effectiveness analyses for these vital treatments.

Area of Science:

  • Cardiology
  • Health Economics
  • Systematic Reviews

Background:

  • Premature coronary artery disease (CAD) necessitates understanding long-term outcomes for effective cost-effectiveness analysis.
  • Revascularization options include coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), alongside medical therapy (MT).

Purpose of the Study:

  • To systematically review and analyze the long-term outcomes of CABG, PCI, and MT in patients with premature CAD.
  • To provide essential data for calculating event probabilities crucial for cost-effectiveness and cost-utility studies.

Main Methods:

  • Systematic review of studies from major databases (PubMed, Web of Science, Scopus, Embase).
  • Inclusion criteria: patients aged 18-60 years.
  • Random-effects meta-analysis to assess long-term outcomes, reporting risk ratios and adverse event probabilities.

Main Results:

  • The study will ascertain probabilities of adverse events over specific periods for each treatment modality.
  • Outcomes will be compared based on specific patient characteristics.

Conclusions:

  • This systematic review offers critical insights into the long-term outcomes of CABG, PCI, and MT for premature CAD.
  • The findings are valuable for both clinical decision-making and economic evaluations, including cost-effectiveness and cost-utility analyses.
Abstract

Keywords:
Cost-effectivenesspremature coronary artery diseaserevascularization

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