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Updated: Oct 16, 2025

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
Evolution of nucleic acids biosensors detection limit III
Yuan Yuan Zhang1, François-Xavier Guillon1, Sophie Griveau1
1Institute of Chemistry for Life and Health Sciences (iCLeHS), Synthesis, Electrochemistry, Imaging and Analytical Systems for Diagnosis (SEISAD) Team, PSL Research University, CNRS, Chimie ParisTech, 75231, Paris, France.
Abstract:
This review is an update of two previous ones focusing on the limit of detection of electrochemical nucleic acid biosensors allowing direct detection of nucleic acid target (miRNA, mRNA, DNA) after hybridization event. A classification founded on the nature of the electrochemical transduction pathway is established. It provides an overall picture of the detection limit evolution of the various sensor architectures developed during the last three decades and a critical report of recent strategies.

