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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

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The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
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Related Experiment Video

Updated: Oct 16, 2025

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
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Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

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Fracture Risk Following an Atypical Femoral Fracture.

Marie-Josée Bégin1, Marie-Claude Audet1, Thierry Chevalley1

  • 1Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|October 20, 2021
PubMed
Summary
This summary is machine-generated.

Patients experiencing atypical femoral fractures (AFFs) face a high risk of subsequent fragility fractures, similar to those with peripheral major osteoporotic fractures (pMOFs). Continued anti-resorptive drug use post-AFF increases contralateral AFF risk, necessitating further research into optimal prevention strategies.

Keywords:
ANTIRESORPTIVESDISEASES AND DISORDERS OF/RELATED TO BONEFRACTURE RISK ASSESSMENTOSTEOPOROSISTHERAPEUTICS

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Last Updated: Oct 16, 2025

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
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Area of Science:

  • Orthopedics
  • Endocrinology
  • Gerontology

Background:

  • Atypical femoral fractures (AFFs) are a known complication of osteoporosis treatment, often leading to the cessation of anti-resorptive (AR) drugs.
  • The subsequent fracture risk for patients who have experienced an AFF is not well-established.
  • Understanding this risk is crucial for optimizing secondary fracture prevention strategies.

Purpose of the Study:

  • To investigate the incidence of subsequent low-trauma fractures in patients who have sustained an atypical femoral fracture (AFF).
  • To compare the risk of subsequent fractures in AFF patients with that of patients who experienced a peripheral major osteoporotic fracture (pMOF).
  • To evaluate the impact of continued anti-resorptive (AR) drug therapy on fracture risk after an AFF.

Main Methods:

  • A follow-up study comparing 55 patients with AFF to 165 matched controls with pMOF (hip fractures being predominant).
  • Patients were matched for age and gender and followed within a fracture liaison service setting.
  • Incidence rates of subsequent low-trauma, major osteoporotic, and imminent fractures were analyzed, along with the risk of multiple fractures and mortality.

Main Results:

  • The risks of new low-trauma, major osteoporotic, and imminent fractures were similar between the AFF and pMOF groups.
  • Patients with AFF had a significantly increased risk of sustaining multiple fractures compared to the pMOF group (HR 1.48).
  • Continuation of AR drugs after an AFF was associated with a 27% incidence of contralateral AFF.

Conclusions:

  • Patients experiencing an AFF are at a high risk for subsequent fragility fractures, comparable to or greater than that following a pMOF.
  • Continuation of anti-resorptive therapy post-AFF is linked to an increased risk of contralateral AFF.
  • Further research is needed to determine optimal secondary fracture prevention strategies for patients with AFF.