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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Cellular senescence and its impact on the circadian clock
Rezwana Ahmed1, Hasan Mahmud Reza1, Kazuyuki Shinohara2
1Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
Journal of Biochemistry
|October 20, 2021
Summary
Cellular senescence, a key driver of aging, may disrupt the body's internal clock. This review explores how senescent cells contribute to age-related diseases and circadian rhythm disruption.
Area of Science:
- Gerontology
- Cellular Biology
- Chronobiology
Background:
- Aging is a primary risk factor for chronic non-communicable diseases.
- Cellular senescence, the accumulation of non-dividing cells, is a major contributor to aging and age-related conditions.
- Senescent cells disrupt tissue function and are linked to various age-related diseases.
Purpose of the Study:
- To review the fundamental characteristics and detrimental roles of cellular senescence.
- To explore the connection between cellular senescence and the circadian clock.
- To investigate if cellular senescence underlies circadian clock disruption in aging.
Main Methods:
- Literature review of cellular senescence.
- Analysis of the relationship between cellular senescence and circadian rhythms.
- Discussion of the potential causal link between senescence and circadian disruption.
Main Results:
- Cellular senescence contributes to tissue dysfunction and age-related diseases.
- Aging is associated with disruptions in the circadian clock system.
- Evidence suggests a potential role for cellular senescence in circadian clock dysregulation.
Conclusions:
- Cellular senescence is a significant factor in aging and age-related diseases.
- Circadian clock disruption is a hallmark of aging, contributing to various pathologies.
- Further research is needed to fully elucidate the role of cellular senescence in circadian rhythm disruption and its implications for healthspan.
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