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Updated: Oct 16, 2025

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation
Paolo Seccamani1, Chiara Franco1, Stefano Protti1
1Department of Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy.
Abstract:
Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.
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