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Bullous Dermatoses and Depression: A Systematic Review
Sarah P Pourali1, Yasmin Gutierrez2, Alison H Kucharik3
1Vanderbilt University School of Medicine, Nashville, Tennessee.
JAMA Dermatology
|October 20, 2021
Summary
Patients with bullous skin diseases experience high rates of depression and depressive symptoms. Effective treatment of these dermatological conditions may alleviate the associated mental health burden.
Area of Science:
- Dermatology and Psychiatry
- Epidemiology of Chronic Diseases
Background:
- Bullous skin diseases are associated with significant psychological distress.
- A comprehensive synthesis of evidence linking bullous dermatoses and depression is lacking.
Purpose of the Study:
- To systematically review and interpret existing literature on the association between bullous skin disease and depression.
- To quantify the prevalence of depressive symptoms and diagnosed depression in patients with bullous dermatoses.
Main Methods:
- A systematic literature search was conducted across PubMed, Embase, PsycInfo, and Cochrane databases (1945-February 2021).
- PRISMA guidelines were followed, and study quality was assessed using the Newcastle-Ottawa Scale.
- The review was registered with PROSPERO (CRD42021230750).
Main Results:
- Seventeen articles analyzing 83,910 patients were included.
- Prevalence of depressive symptoms ranged from 40% to 80%; diagnosed depression ranged from 11.4% to 28% in patients with bullous dermatoses.
- Specific conditions analyzed included bullous pemphigoid, pemphigus, and epidermolysis bullosa.
Conclusions:
- Patients with bullous skin diseases exhibit high rates of depression and depressive symptoms.
- Effective management of bullous dermatoses may reduce the psychological impact on patients.
- Highlights the need for integrated dermatological and psychiatric care.
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