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[Vitamin D and pregnancy].

Béatrice Eggel-Hort1, Emeline Maisonneuve2,3, Elena Gonzalez Rodriguez4

  • 1Service de gynécologie et obstétrique, Centre hospitalier du Valais Romand, 1951 Sion.

Revue Medicale Suisse
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Summary
This summary is machine-generated.

Vitamin D deficiency is common and linked to pregnancy complications. Supplementation is suggested due to safety, even if benefits aren't fully proven, possibly before conception.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Immunology

Background:

  • Vitamin D deficiency is prevalent globally, affecting over 50% of the population.
  • Maternal vitamin D insufficiency is linked to adverse pregnancy outcomes, including miscarriage and preterm birth.
  • Vitamin D modulates the immune system, which undergoes significant changes during pregnancy.

Purpose of the Study:

  • To review the association between vitamin D deficiency and pregnancy complications.
  • To discuss the potential role of vitamin D supplementation during pregnancy.
  • To evaluate the safety and timing of vitamin D substitution in obstetric care.

Main Methods:

  • Literature review of studies investigating vitamin D levels in pregnancy.
  • Analysis of the impact of hypovitaminosis D on maternal and fetal health outcomes.
  • Assessment of the immunological role of vitamin D in pregnancy.

Main Results:

  • Vitamin D deficiency is associated with increased risks of miscarriage, preeclampsia, gestational diabetes, and low birth weight.
  • Hypovitaminosis D may contribute to postpartum hemorrhage.
  • The immunomodulatory effects of vitamin D are crucial during pregnancy.

Conclusions:

  • Vitamin D supplementation should be considered for pregnant individuals due to its safety profile.
  • Substitution may be beneficial even with limited evidence on optimal timing.
  • Considering supplementation before conception is a potential strategy.