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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
[Precorneal tear film after corneal collagen cross-linking in keratoconus (preliminary report)]
G V Voronin1,2, I A Bubnova1, V V Averich1
1Research Institute of Eye Diseases, Moscow, Russia.
Purpose:
To study the condition of precorneal tear film in keratoconus patients after corneal collagen cross-linking (CXL).
Material And Methods:
The study enrolled 24 patients (30 eyes) with stages I-III progressive keratoconus. All study patients underwent standard (Dresden) protocol CXL. Patients were examined before the surgery and 1 week, 1 month, and 3 months postoperatively. The condition of precorneal tear film was evaluated based on the results of Norn test (the tear film break-up time), Schirmer test, Jones test, optical coherence tomography based lacrimal meniscometry, and improved tearscopy.
Results:
One month after CXL, patients with keratoconus experienced transient changes in the precorneal tear film condition - the tear film break-up time was reduced, the tear secretion was elevated, the lacrimal meniscus biometry parameters were increased, and the thickness of the tear film lipid layer was decreased.
Conclusion:
Corneal changes resulting from CXL lead to transient disorders of the mucin and lipid layers of the precorneal tear film, which requires adequate tear substitute therapy in the postoperative period.
