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Smoking tobacco is associated with renal hyperfiltration
Malin Mickelsson1, Elisabet Söderström2, Kristina Stefansson1
1Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
Scandinavian Journal of Clinical and Laboratory Investigation
|October 20, 2021
Summary
Active smoking is linked to a higher estimated glomerular filtration rate (eGFR) based on creatinine, suggesting potential renal hyperfiltration. Snus use showed no impact on eGFR, indicating smoking-specific effects.
Area of Science:
- Nephrology
- Toxicology
- Public Health
Background:
- Tobacco consumption is a known renal risk factor.
- The precise impact of smoking and snus on estimated glomerular filtration rate (eGFR) requires further elucidation.
Purpose of the Study:
- To investigate the association between tobacco product use (smoking and snus) and eGFR, utilizing both creatinine and cystatin C as biomarkers.
- To differentiate the renal effects of active smoking versus snus consumption.
Main Methods:
- Utilized two cohorts (n=949 and n=995) without pre-existing renal disease.
- Employed hierarchical multiple linear regression models to analyze the relationship between tobacco use and eGFR.
- Collected data via blood samples and detailed questionnaires on tobacco habits.
Main Results:
- Active smoking was independently associated with a significantly higher eGFR measured by creatinine (eGFRcreatinine) across all participants, men, and women.
- A significant association between active smoking and eGFR measured by cystatin C (eGFRcystatin C) was observed in the overall cohort but not after sex stratification.
- Snus consumption did not show any significant association with eGFR.
Conclusions:
- Smoking is significantly associated with elevated eGFRcreatinine, potentially indicating renal hyperfiltration of creatinine.
- The observed effect is likely attributable to components in smoked tobacco other than nicotine, as snus use did not yield similar results.
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