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Updated: Oct 16, 2025
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019-2021
Salvatore Grisanti1, Deborah Cosentini1, Sandra Sigala2
1Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili.
Purpose Of Review:
comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC.
Recent Findings:
423 studies were published between 2019 and 2021. After manual curation we summarized selected evidence in two thematic areas: germline deoxyribonucleic acid (DNA) variations, genomic alterations and prognosis.
Summary:
the evolving genomic landscape of ACC requires target validation in terms of prognostic and predictive value within scientific consortia. Although the existing multiple driver genes are difficult targets in the perspective of precision oncology, alterations in DNA damage repair genes or in promoter hypermethylation could open new venues for repurposing of existing drugs in ACC.
Insights
Genomic analysis of adrenocortical carcinoma (ACC) reveals potential therapeutic targets. Reviewing recent studies highlights germline DNA variations and genomic alterations for improved prognosis and precision oncology drug repurposing.
Area of Science:
- Endocrinology
- Oncology
- Genomics
Background:
- Adrenocortical carcinoma (ACC) is a rare endocrine malignancy.
- Comprehensive molecular characterization is crucial for identifying prognostic and therapeutic targets.
Purpose of the Study:
- To critically review recent literature on the genotyping of ACC.
- To summarize evidence on germline DNA variations, genomic alterations, and prognosis in ACC.
Main Methods:
- Systematic literature search of studies published between 2019 and 2021.
- Manual curation and thematic summarization of selected evidence.
Main Results:
- Analysis of 423 studies identified key themes in ACC genomics.
- Germline deoxyribonucleic acid (DNA) variations and genomic alterations are linked to prognosis.
Conclusions:
- The evolving genomic landscape of ACC necessitates target validation for prognostic and predictive value.
- Alterations in DNA damage repair genes or promoter hypermethylation may offer new avenues for drug repurposing in ACC, advancing precision oncology.
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